Some tumor suppressor proteins, including p63, p73, 14-3-3 sigma, maspin and Wilms Tumor (WT-1) have been preferentially detected in myoepithelial cells. The myoepithelial cells express typical cytokeratins of the basal layer of stratified epithelia (CK5, CK14, and CK17), filamentous α-smooth muscle actin (SMA) and the heavy chain-myosin (hc-myosin). Myoepithelial basal cells are localized between luminal epithelial cells and the stroma, which place them in an ideal position in order to communicate with both compartments. Most lesions exhibit epithelial alterations however, some mammary lesions show myoepithelial changes. ![]() ![]() Proliferative lesions of the mammary gland arise mainly in the terminal duct lobular unit (TDLU).
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